SCHEMBL551067

SCHEMBL551067

Nc1ccc(O)c(C(F)(F)F)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.61
GAA P10253 3/20 0.61
GLA P06280 1/20 0.61
POLB P06746 1/20 0.61
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
PDE10A Q9Y233 1/20 0.46
HSD17B1 P14061 2/20 0.43
HSD17B2 P37059 2/20 0.43
KIF11 P52732 2/20 0.42
CASP1 P29466 3/20 0.42
HSD17B10 Q99714 3/20 0.42
KDM4E B2RXH2 3/20 0.42
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 2/20 0.42
HPGD P15428 2/20 0.42
CASP7 P55210 2/20 0.42
KMT2A Q03164 2/20 0.42
ALOX15 P16050 2/20 0.42
CYP3A4 P08684 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29549724 1.00 TSHR (0.61) TSHRGAAGLAPOLBCA1
SCHEMBL29585248 0.82 GAA (0.56) TSHRGAAGLAPOLBCA1
SCHEMBL2012586 0.82 GAA (0.56) TSHRGAAGLAPOLBCA1
SCHEMBL29420085 0.78 TSHR (0.70) TSHRGAAGLAPOLBKIF11
SCHEMBL827884 0.78 TSHR (0.70) TSHRGAAGLAPOLBKIF11
SCHEMBL2874961 0.77 ALDH1A1 (0.61) TSHRGAACA1CA2PDE10A
SCHEMBL28651917 0.77 GAA (0.60) TSHRGAAGLAPOLBCA1
SCHEMBL109685 0.76 TSHR (1.00) TSHRGAAGLAPOLBKIF11
SCHEMBL17451259 0.76 TSHR (1.00) TSHRGAAGLAPOLBKIF11
SCHEMBL1938893 0.76 HSD17B1 (0.65) HSD17B1HSD17B2KIF11ARAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 403 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117247515-A Polyimide containing Trringer's Base element and gas separation membrane and method prepared by polyimide 西北工业大学 2023-12-19 CN claimed
CN-116854679-A Novel epoxy resin containing imide unit and preparation method thereof 西北工业大学 2023-10-10 CN claimed
CN-116854913-A Preparation method of high-impact-resistance bismaleimide resin 西北工业大学 2023-10-10 CN claimed
CN-111303426-B Polyimide film and method for preparing polyimide film by click chemistry 西北工业大学 2022-07-05 CN claimed
CN-110229158-B Thermosetting polyimide precursor with low melt viscosity and suitable for RTM (resin transfer molding) and preparation method thereof 西北工业大学 2022-06-07 CN claimed
CN-110218287-B High-performance self-repairing polyimide based on dynamic imine bond and preparation method thereof 西北工业大学 2022-03-15 CN claimed
CN-109824894-B Preparation method of polyimide film with molecular main chain alternately composed of two acid anhydrides 西北工业大学 2021-08-10 CN claimed
CN-106990673-B Transparent and photosensitive polyimide resin composition 浙江福斯特新材料研究院有限公司 2021-06-11 CN claimed
CN-111410891-A Self-adhesive corona-resistant polyimide paint, enameled wire and preparation method thereof 苏州巨峰电气绝缘系统股份有限公司 2020-07-14 CN claimed
CN-111303426-A Polyimide film and method for preparing polyimide film by click chemistry 西北工业大学 2020-06-19 CN claimed
CN-103122232-A 2,2-di[4-(2,4-diamino phenoxy) phenyl] propane form high-temperature epoxy adhesive and preparation method thereof UNIV DONGHUA 2013-05-29 CN claimed
CN-102942310-A Organosilicon polyimide benzimidazole photoconductive fiber coating layer and preparation method thereof UNIV DONGHUA 2013-02-27 CN claimed
CN-102910840-A High-temperature resistant benzimidazole optical fiber coating and preparation method of coating UNIV DONGHUA 2013-02-06 CN claimed
CN-102911595-A Benzimidazole-type humidity-sensitive high-molecular coating material and preparation method and application thereof UNIV DONGHUA 2013-02-06 CN claimed
US-20080139795-A1 Preparation of halogenated 4-aminophenols LANXESS DEUTSCHLAND GMBH (DE) 2008-06-12 US claimed
US-20050143425-A1 Preparation of halogenated 4-aminophenols LANXESS DEUTSCHLAND GMBH (DE) 2005-06-30 US claimed
CN-1616412-A Process for the preparation of halogen containing 4-amino phenols BAYER CHEMICALS AG (DE) 2005-05-18 CN claimed
EP-1514865-A1 Process for the preparation of halogen containing 4-amino phenols Bayer Chemicals AG (DE) 2005-03-16 EP claimed
EP-0299497-B1 Dye composition for keratinous fiber KAO CORP (JP) 1994-02-16 EP claimed
US-4871372-A AS DEVELOPER A TRIFLUOROMETHYLATED P-PHENYLENEDIAMINE KAO CORPORATION (JP) 1989-10-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080139795-A1 Preparation of halogenated 4-aminophenols CYP4X1, CYP4B1, PAH TSHR 814/4885GAA 2584/4885GLA 4375/4885
US-20050143425-A1 Preparation of halogenated 4-aminophenols CYP4X1, HPD, CYP4F8 TSHR 842/4885GAA 2817/4885GLA 4162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.