Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514969 | 0.81 | ACHE (0.43) | ALDH1A1APOBEC3GGAAKDM4EHPGD | |
| SCHEMBL5510005 | 0.81 | APOBEC3G (0.38) | ALDH1A1APOBEC3GGAAKDM4EHPGD | |
| SCHEMBL8978590 | 0.75 | DCUN1D1 (0.57) | ALDH1A1APOBEC3GGAAKDM4EHPGD | |
| SCHEMBL23623635 | 0.74 | GAA (0.42) | ALDH1A1APOBEC3GGAAPOLBMPI | |
| SCHEMBL5507371 | 0.72 | NOTUM (0.44) | ALDH1A1APOBEC3GGAAKDM4EHPGD | |
| SCHEMBL10741401 | 0.70 | PDE5A (0.49) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL10744015 | 0.70 | PDE2A (0.48) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL26036243 | 0.70 | PTGS2 (0.48) | ALDH1A1PTGS2CA2 | |
| SCHEMBL14345178 | 0.69 | ALDH1A1 (0.45) | ALDH1A1GAAKDM4EHPGDKMT2A | |
| SCHEMBL9634654 | 0.69 | PDE5A (0.53) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8968708-B2 | Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions | SENOMYX, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8784782-B2 | Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions | SENOMYX, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20130071536-A1 | COMPOUNDS COMPRISING LINKED HETEROARYL MOIETIES AND THEIR USE AS NOVEL UMAMI FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS FOR COMESTIBLE COMPOSITIONS | SENOMYX, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| EP-1850681-A2 | COMPOUNDS COMPRISING LINKED HETERO ARYL MOIETIES AND THEIR USE AS NOVEL UMAMI FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS FOR COMESTIBLE COMPOSITIONS | Senomyx, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| US-20060263411-A1 | Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions | SENOMYX, INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006084186-A2 | COMPOUNDS COMPRISING LINKED HETERO ARYL MOIETIES AND THEIR USE AS NOVEL UMAMI FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS FOR COMESTIBLE COMPOSITIONS | SENOMYX, INC. (US) | 2006-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060263411-A1 | Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions | TAS2R46, TAS2R30, TAS2R50 | ALDH1A1 248/4885APOBEC3G 1796/4885GAA 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.