Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898650 | 0.78 | NOS1 (0.37) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL14324206 | 0.77 | CHEK1 (0.44) | NOS1 | |
| SCHEMBL1894901 | 0.74 | KMT2A (0.44) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL14323570 | 0.71 | PIM1 (0.41) | KDM4EGLAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14323875 | 0.70 | ELANE (0.38) | GAAKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL1897854 | 0.67 | ELANE (0.43) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL6383953 | 0.63 | HTT (0.49) | GAAKDM4EALDH1A1HPGDATM | |
| Bicarbonate SCHEMBL10870596 | 0.62 | TDP1 (0.75) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL730937 | 0.62 | MAOA (0.44) | KDM4EGLAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16541139 | 0.61 | GPR3 (0.48) | KDM4EALDH1A1HPGDCYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869043-A2 | PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107853-A2 | PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |