Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | QDPR | P09417 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | FGR | P09769 | 1/20 | 0.31 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.31 |
| ▸ | TXK | P42681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507937 | 0.89 | PIM1 (0.37) | PIM1MKNK1MKNK2KDM4ENPC1 | |
| SCHEMBL5119736 | 0.83 | PIM1 (0.40) | PIM1BRAFMAPK3MAPK1CDC7 | |
| SCHEMBL5509159 | 0.82 | DRD4 (0.43) | — | |
| SCHEMBL5507880 | 0.82 | PIM1 (0.35) | PIM1CACNA1B | |
| SCHEMBL5507199 | 0.81 | DRD2 (0.43) | MAPK1KDM4EHTR2A | |
| SCHEMBL5502548 | 0.80 | L3MBTL1 (0.40) | MAPK1KDM4EL3MBTL1 | |
| SCHEMBL5505023 | 0.79 | PIM1 (0.39) | PIM1MAPK1L3MBTL1CACNA1BHTR2A | |
| SCHEMBL5508370 | 0.79 | PARP2 (0.35) | KDM4EHTR2AHTR2C | |
| SCHEMBL5503010 | 0.77 | PIM1 (0.38) | PIM1CACNA1BHTR2C | |
| SCHEMBL5503892 | 0.77 | QDPR (0.36) | PIM1BRAFMAPK3MAPK1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |