Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5125239 | 0.84 | PIM1 (0.40) | PIM1PARP1PARP2CACNA1BP2RX4 | |
| SCHEMBL5505023 | 0.80 | PIM1 (0.39) | PIM1CACNA1BP2RX4MAPTHTR2C | |
| SCHEMBL5511892 | 0.77 | PIM1 (0.37) | PIM1CACNA1BHTR2C | |
| SCHEMBL5503522 | 0.76 | P2RX4 (0.46) | P2RX4MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL38662568 | 0.75 | PIM1 (0.49) | PIM1CACNA1BP2RX4MAPTHTR2C | |
| SCHEMBL5507937 | 0.75 | PIM1 (0.37) | PIM1 | |
| SCHEMBL5507880 | 0.74 | PIM1 (0.35) | PIM1CACNA1B | |
| SCHEMBL5507953 | 0.74 | P2RX4 (0.46) | P2RX4MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL5503754 | 0.73 | OPRM1 (0.45) | MAPTTSHROPRM1OPRK1 | |
| SCHEMBL5115249 | 0.70 | OPRD1 (0.47) | P2RX4CYP2D6OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |