Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TARDBP | Q13148 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506636 | 0.75 | KCNH2 (0.56) | KDM4EKMT2AMCHR1TARDBP | |
| SCHEMBL5507574 | 0.72 | KMT2A (0.43) | KMT2AALDH1A1MAPTHTTROCK2 | |
| SCHEMBL5514123 | 0.69 | KCNH2 (0.55) | KDM4ETARDBP | |
| SCHEMBL21583768 | 0.65 | RAB9A (0.65) | KDM4EKMT2AALDH1A1MAPTGAA | |
| SCHEMBL3256176 | 0.65 | KMT2A (0.50) | KDM4EKMT2AMCHR1ALDH1A1MAPT | |
| SCHEMBL22831686 | 0.65 | KDM4E (0.59) | KDM4EKMT2AMCHR1ALDH1A1GAA | |
| SCHEMBL20281671 | 0.64 | PDE2A (0.59) | KDM4EKMT2AMCHR1ALDH1A1ROCK2 | |
| SCHEMBL4502213 | 0.63 | KCNH2 (0.79) | — | |
| Hydrochloric Acid SCHEMBL695049 | 0.63 | KMT2A (0.69) | KDM4EKMT2AMCHR1ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL4498090 | 0.63 | KCNH2 (0.78) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | claimed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | claimed |