Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenethiol SCHEMBL5512763 | 0.87 | LMNA (0.48) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 | |
| Biphenyl SCHEMBL27496289 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 | |
| Benzene SCHEMBL27573082 | 0.78 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 | |
| Benzenethiol SCHEMBL9278143 | 0.78 | — | — | |
| Benzene SCHEMBL6829333 | 0.78 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 | |
| Benzenethiol SCHEMBL5698196 | 0.78 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2TSHRMAPT | |
| Biphenyl SCHEMBL27994032 | 0.76 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 | |
| Biphenyl SCHEMBL2642362 | 0.76 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 | |
| Toluene SCHEMBL5070511 | 0.75 | LMNA (0.55) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 | |
| Chlorobenzene SCHEMBL14685881 | 0.75 | TSHR (0.55) | ALDH1A1LMNASMN1; SMN2CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39821-E1 | Manufacture and expression of large structural genes | INTERMUNE, INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-6936695-B1 | Manufacture and expression of large structural genes | INTERMUNE, INC. (US) | 2005-08-30 | — | — | US | disclosed |
| US-6936694-B1 | [Met--1, des-Cys1, des-Tyr2, des-Cys3]IFN- gamma polypeptide produced by a DNA sequence coding in a transformant organism, and such polypeptide having the characteristics of human immune interferon | INTERMUNE, INC. (US) | 2005-08-30 | — | — | US | disclosed |
| US-5661009-A | PROVIDING HOST CELL TRANSFORMED WITH DNA ENCODING A CONSENSUS HUMAN LEUKOCYTE INTERFERON, CULTURING CELL TO EFFECT EXPRESSION OF DNA | AMGEN INC. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5541293-A | Consensus human leukocyte interferon | AMGEN INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0423845-B1 | A synthetic gene encoding gamma-interferon | AMGEN INC (US) | 1994-12-14 | — | — | EP | disclosed |
| EP-0424990-B1 | The manufacture and expression of large structural genes | AMGEN INC (US) | 1994-06-22 | — | — | EP | disclosed |
| EP-0108128-B1 | (MET-1,DES-CYS1,DES-TYR2,DES-CYS3) HUMAN GAMMA INTERFERON AND A DNA SEQUENCE ENCODING IT | AMGEN INC. (US) | 1991-12-18 | — | — | EP | disclosed |
| EP-0424990-A1 | The manufacture and expression of large structural genes | AMGEN INC. (US) | 1991-05-02 | — | — | EP | disclosed |
| EP-0423845-A1 | A synthetic gene encoding gamma-interferon | AMGEN INC. (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4695623-A | Consensus human leukocyte interferon | AMGEN (US) | 1987-09-22 | — | — | US | disclosed |
| EP-0108128-A4 | (Met-1,des-Cys1,des-Tyr2,des-Cys3) human gamma interferon and a DNA sequence encoding it. | AMGEN (US) | 1986-09-15 | — | — | EP | disclosed |
| EP-0136489-A1 | Analogs of human interleukin II and their preparation | AMGEN INC. (US) | 1985-04-10 | — | — | EP | disclosed |
| EP-0135094-A1 | Microbial expression of insulin-like growth factor | AMGEN INC. (US) | 1985-03-27 | — | — | EP | disclosed |
| WO-1985000831-A1 | MICROBIAL EXPRESSION OF INSULIN-LIKE GROWTH FACTOR | AMGEN (US) | 1985-02-28 | — | — | WO | disclosed |
| WO-1985000817-A1 | MICROBIAL EXPRESSION OF INTERLEUKIN II | AMGEN (US) | 1985-02-28 | — | — | WO | disclosed |
| EP-0108128-A1 | (Met-1,des-Cys1,des-Tyr2,des-Cys3) human gamma interferon and a DNA sequence encoding it. | AMGEN (US) | 1984-05-16 | — | — | EP | disclosed |
| EP-0108132-A1 | THE MANUFACTURE AND EXPRESSION OF GENES FOR UROGASTRONE AND POLYPEPTIDE ANALOGS THEREOF | APPLIED MOLECULAR GENETICS INC. (US) | 1984-05-16 | — | — | EP | disclosed |
| WO-1983004030-A1 | THE MANUFACTURE AND EXPRESSION OF GENES FOR UROGASTRONE AND POLYPEPTIDE ANALOGS THEREOF | APPLIED MOLECULAR GENETICS, INC. (US) | 1983-11-24 | — | — | WO | disclosed |
| WO-1983004053-A1 | THE MANUFACTURE AND EXPRESSION OF LARGE STRUCTURAL GENES | APPLIED MOLECULAR GENETICS, INC. (US) | 1983-11-24 | — | — | WO | disclosed |