Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2-Phenylphenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HNF4A | P41235 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Phenylphenol SCHEMBL28188057 | 0.91 | ALDH1A1 (0.71) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL2415939 | 0.91 | ALDH1A1 (0.85) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL27504029 | 0.91 | ALDH1A1 (0.85) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL8986460 | 0.88 | HPGD (0.90) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL29811 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| SCHEMBL28366972 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL29360750 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL14249267 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL27831345 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| 2-Phenylphenol SCHEMBL8958563 | 0.88 | ALDH1A1 (0.65) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103446718-B | Golf and its manufacture method | DUNLOP SPORTS CO., LTD. (JP) | 2016-01-20 | — | — | CN | disclosed |
| CN-105148462-A | Golf ball | DUNLOP SPORTS CO LTD | 2015-12-16 | — | — | CN | disclosed |
| CN-103418118-B | The manufacture method of golf | DUNLOP SPORTS CO., LTD. (JP) | 2015-11-18 | — | — | CN | disclosed |
| CN-103446717-B | Golf ball | DUNLOP SPORTS Co.,Ltd. (JP) | 2015-11-18 | — | — | CN | disclosed |
| US-8821908-B2 | Mold-resistant construction materials | HENKEL AG & CO. KGAA (DE) | 2014-09-02 | — | — | US | disclosed |
| CN-103446717-A | Golf ball | DUNLOP SPORTS CO LTD | 2013-12-18 | — | — | CN | disclosed |
| CN-103446719-A | Golf ball | DUNLOP SPORTS CO LTD | 2013-12-18 | — | — | CN | disclosed |
| CN-103446718-A | Golf ball and method for manufacturing the same | DUNLOP SPORTS CO LTD | 2013-12-18 | — | — | CN | disclosed |
| CN-103418118-A | Method for manufacturing a golf ball | DUNLOP SPORTS CO LTD | 2013-12-04 | — | — | CN | disclosed |
| US-20070224250-A1 | MOLD-RESISTANT CONSTRUCTION MATERIALS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070155835-A1 | USE OF ORTHO-PHENYLPHENOL AND/OR DERIVATIVES THEREOF FOR INHIBITING THE ASEXUAL REPRODUCTION OF FUNGI | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2007-07-05 | — | — | US | disclosed |
| WO-2004039762-A1 | PHENETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2004-05-13 | — | — | WO | disclosed |
| US-4342473-A | Pressure-sensitive copy systems containing phenolic ester as color-stabilizers | CHAMPION INTERNATIONAL CORPORATION (US) | 1982-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070224250-A1 | MOLD-RESISTANT CONSTRUCTION MATERIALS | ERG28, DCXR, MGAM | ALDH1A1 999/4885HPGD 590/4885BCL2L1 2631/4885 |
| US-20070155835-A1 | USE OF ORTHO-PHENYLPHENOL AND/OR DERIVATIVES THEREOF FOR INHIBITING THE ASEXUAL REPRODUCTION OF FUNGI | TYR, HPD, ERG28 | ALDH1A1 1350/4885HPGD 2831/4885BCL2L1 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.