Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.43 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.43 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29092883 | 0.82 | HTR6 (0.53) | MAPTPOLBMEN1KMT2ACACNB4 | |
| SCHEMBL26581664 | 0.82 | SLC22A12 (0.50) | PTGER3THRBTHRA | |
| SCHEMBL1924422 | 0.77 | PTGER3 (0.52) | PTGER3 | |
| SCHEMBL24824798 | 0.77 | CYP19A1 (0.44) | GAAMAPT | |
| SCHEMBL20787916 | 0.74 | CACNB4 (0.51) | GAAMAPTCACNB4CACNA1ACACNA1G | |
| SCHEMBL1925953 | 0.74 | PTGER3 (0.49) | PTGER3CACNA1GCACNA1HCACNA1I | |
| SCHEMBL1926098 | 0.73 | PTGER3 (0.56) | PTGER3MAPTTHRBTHRA | |
| SCHEMBL12225809 | 0.73 | POLB (0.63) | MAPTPOLBMEN1KMT2ATP53 | |
| SCHEMBL25500049 | 0.73 | ICMT (0.43) | MAPTPOLBMEN1KMT2A | |
| SCHEMBL18508845 | 0.72 | ALDH1A1 (0.65) | GAAMAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812426-A1 | ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE | Decode Genetics, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044405-A1 | ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE | DECODE GENETICS, INC. (US) | 2006-04-27 | — | — | WO | disclosed |