Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274425 | 1.00 | HDAC4 (0.34) | HDAC4HDAC7HDAC8HDAC6HDAC9 | |
| SCHEMBL5516799 | 0.76 | CYP2D6 (0.32) | NPSR1HSD17B10 | |
| SCHEMBL781662 | 0.74 | TBXAS1 (0.40) | — | |
| SCHEMBL781661 | 0.74 | TBXAS1 (0.40) | — | |
| SCHEMBL22660988 | 0.70 | ALDH1A1 (0.36) | HDAC4HDAC7HDAC8HDAC6HDAC9 | |
| SCHEMBL503650 | 0.70 | ALDH1A1 (0.36) | HDAC4HDAC7HDAC8HDAC6HDAC9 | |
| SCHEMBL5521550 | 0.70 | HDAC1 (0.39) | HDAC4HDAC7HDAC8HDAC6HDAC9 | |
| SCHEMBL7647878 | 0.69 | — | — | |
| SCHEMBL385711 | 0.68 | L3MBTL1 (0.36) | POLBHTTSMN1; SMN2TP53MAPT | |
| SCHEMBL385712 | 0.68 | L3MBTL1 (0.36) | POLBHTTSMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373549-B1 | AMINO ACID DERIVATIVES WITH ENZYME-INHIBITING PROPERTIES, PROCESS TO SYNTHETISE THEM, COMPOSITION CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-01 | — | — | EP | claimed |
| US-5204357-A | RENIN-INHIBITING AMINO ACID DERIVATIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-04-20 | — | — | US | claimed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | claimed |
| EP-0394853-A1 | Dipeptide-derivatives with enzym-inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-10-31 | — | — | EP | claimed |
| EP-0373497-A2 | Dipeptide derivatives with an enzyme-inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-20 | — | — | EP | claimed |
| EP-0373549-A2 | Amino acid derivatives with enzyme-inhibiting properties, process to synthetise them, composition containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-20 | — | — | EP | claimed |
| EP-0372537-A2 | Urea derivatives of dipeptides with enzyme-inhibiting properties, process to make them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-13 | — | — | EP | claimed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | claimed |
| EP-0370383-A2 | Renin-inhibiting dipeptides, process to make them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | claimed |
| EP-0329013-A2 | Renin-inhibiting amino acid derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-23 | — | — | EP | claimed |
| EP-1470258-B1 | COMPOSITION AND ITS USE FOR IMPARTING WATER REPELLENCY TO LEATHER OR FURSKINS, TEXTILES AND OTHER FIBROUS MATERIALS | TFL LEDERTECHNIK GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |
| US-7250456-B2 | Composition and its use for imparting water repellency to leather or furskins, textiles and other fibrous materials | TFL LEDERTECHNIK GMBH (DE) | 2007-07-31 | — | — | US | disclosed |
| US-20050148702-A1 | Composition and its use for imparting water repellency to leather or furskins, textiles and other fibrous materials | TFL LEDERTECHNIK GMBH (DE) | 2005-07-07 | — | — | US | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| US-5360791-A | Renin-inhibiting aminodiol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| EP-0373497-A2 | Dipeptide derivatives with an enzyme-inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-20 | — | — | EP | disclosed |
| EP-0372537-A2 | Urea derivatives of dipeptides with enzyme-inhibiting properties, process to make them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-13 | — | — | EP | disclosed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0370383-A2 | Renin-inhibiting dipeptides, process to make them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0329013-A2 | Renin-inhibiting amino acid derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-23 | — | — | EP | disclosed |