Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833087 | 0.80 | LMNA (0.47) | TSHRSMN1; SMN2LMNAF2L3MBTL1 | |
| SCHEMBL11229628 | 0.78 | LMNA (0.45) | TSHRSMN1; SMN2MAPTRAB9ALMNA | |
| SCHEMBL1020413 | 0.78 | TSHR (0.56) | TSHRSMN1; SMN2MAPTLMNAF2 | |
| SCHEMBL27968908 | 0.78 | LMNA (0.49) | TSHRSMN1; SMN2MAPTRAB9ALMNA | |
| SCHEMBL1315543 | 0.77 | LMNA (0.58) | TSHRSMN1; SMN2MAPTLMNAF2 | |
| SCHEMBL16322651 | 0.77 | L3MBTL1 (0.50) | TSHRMAPTRAB9ALMNAL3MBTL1 | |
| SCHEMBL27647867 | 0.76 | TSHR (0.54) | TSHRSMN1; SMN2MAPTLMNAF2 | |
| SCHEMBL27668297 | 0.76 | TSHR (0.54) | TSHRSMN1; SMN2MAPTLMNAF2 | |
| SCHEMBL4818821 | 0.75 | LMNA (0.56) | TSHRSMN1; SMN2MAPTLMNAF2 | |
| SCHEMBL11150957 | 0.75 | TSHR (0.58) | TSHRSMN1; SMN2MAPTLMNAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947345-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | Fondazione Istituto Italiano di Tecnologia (IT) | 2022-02-09 | — | — | EP | disclosed |
| WO-2020202072-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2020-10-08 | — | — | WO | disclosed |
| EP-1828147-A1 | QUINOXALINES AS B-RAF INHIBITORS | AstraZeneca AB (SE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006040568-A1 | QUINOXALINES AS B RAF INHIBITORS | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |