Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509230 | 0.84 | MAPT (0.46) | KDM4ELMNATP53L3MBTL1CNR2 | |
| SCHEMBL5504133 | 0.80 | ALDH1A1 (0.43) | KDM4ELMNAMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL5116144 | 0.77 | SMN1; SMN2 (0.49) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL1557719 | 0.76 | ALDH1A1 (0.46) | CNR2PPARAALDH1A1 | |
| SCHEMBL1545756 | 0.74 | S1PR2 (0.41) | TUBB1CNR2PPARACNR1GAA | |
| SCHEMBL11288589 | 0.71 | — | — | |
| SCHEMBL15019690 | 0.71 | ALDH1A1 (0.46) | KDM4ELMNAMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL11202537 | 0.71 | XDH (0.41) | KDM4ELMNACNR2CNR1ALDH1A1 | |
| SCHEMBL1766003 | 0.70 | PPARA (0.54) | KDM4ELMNAL3MBTL1PPARAALDH1A1 | |
| SCHEMBL8710163 | 0.68 | MAPT (0.41) | KDM4ETP53MAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |