Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509230 | 0.88 | MAPT (0.46) | ALDH1A1MAPTPOLBGABRA1GABRB2 | |
| SCHEMBL1557719 | 0.83 | ALDH1A1 (0.46) | ALDH1A1GABRA1GABRB2 | |
| SCHEMBL11864849 | 0.81 | TACR2 (0.51) | ALDH1A1MAPTPOLBTACR2CYP2C19 | |
| SCHEMBL5518581 | 0.80 | KDM4E (0.39) | ALDH1A1MAPTPOLBL3MBTL1LMNA | |
| SCHEMBL8431075 | 0.80 | LMNA (0.49) | ALDH1A1MAPTPOLBTACR2L3MBTL1 | |
| SCHEMBL9163975 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTPOLBTACR2L3MBTL1 | |
| SCHEMBL4591571 | 0.77 | LMNA (0.48) | ALDH1A1MAPTPOLBTACR2L3MBTL1 | |
| SCHEMBL20819545 | 0.77 | LMNA (0.49) | ALDH1A1MAPTTACR2CYP2D6CYP2C19 | |
| SCHEMBL20615143 | 0.77 | CALM1 (0.58) | ALDH1A1MAPTL3MBTL1LMNAKDM4E | |
| SCHEMBL1812946 | 0.77 | KDM1A (0.45) | ALDH1A1TACR2GABRA1GABRB2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |