Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504133 | 0.88 | ALDH1A1 (0.43) | MAPTALDH1A1POLBGABRA1GABRB2 | |
| SCHEMBL5518581 | 0.84 | KDM4E (0.39) | MAPTALDH1A1POLBCNR2SMN1; SMN2 | |
| SCHEMBL1557719 | 0.81 | ALDH1A1 (0.46) | ALDH1A1GABRA1GABRB2CNR2PKM | |
| SCHEMBL14143944 | 0.78 | CSNK2A1 (0.50) | MAPTALDH1A1POLBCSNK2A1GABRA1 | |
| SCHEMBL30902389 | 0.77 | MAPT (0.55) | MAPTALDH1A1POLBGPR55L3MBTL1 | |
| SCHEMBL5115761 | 0.76 | SMN1; SMN2 (0.64) | MAPTALDH1A1POLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL5144157 | 0.74 | SMN1; SMN2 (0.62) | MAPTALDH1A1CSNK2A1CNR2SMN1; SMN2 | |
| SCHEMBL809741 | 0.74 | MAPT (0.47) | MAPTALDH1A1POLBGPR55CSNK2A1 | |
| SCHEMBL2868462 | 0.73 | CSNK2A1 (0.44) | MAPTALDH1A1POLBGPR55CSNK2A1 | |
| SCHEMBL9163231 | 0.73 | FDPS (0.50) | MAPTALDH1A1SMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |