Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9011499 | 0.74 | TSHR (0.32) | TSHRNFKB1CYP2C19 | |
| SCHEMBL21618364 | 0.74 | TSHR (0.33) | TSHRNFKB1CYP2C19 | |
| SCHEMBL10812173 | 0.72 | TSHR (0.31) | TSHRNFKB1CYP2C19 | |
| SCHEMBL9860220 | 0.69 | TSHR (0.33) | TSHRNFKB1CYP2C19 | |
| SCHEMBL11119942 | 0.69 | — | — | |
| SCHEMBL6492 | 0.67 | TSHR (0.39) | TSHRNFKB1CYP2C19 | |
| SCHEMBL5519012 | 0.67 | GAA (0.33) | — | |
| SCHEMBL4020427 | 0.67 | — | — | |
| SCHEMBL4551793 | 0.67 | — | — | |
| SCHEMBL8469829 | 0.67 | TSHR (0.32) | TSHRNFKB1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3691639-B1 | CHROMANE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3423504-B1 | PROCESS FOR MAKING URETHANE ACRYLATES | DOW GLOBAL TECHNOLOGIES LLC (US) | 2023-05-10 | — | — | EP | disclosed |
| CN-113527543-B | Aqueous neutral piperidine nitrogen-oxygen free radical organic flow battery electrolyte, battery and preparation method | 西安交通大学 | 2022-12-09 | — | — | CN | disclosed |
| US-11433055-B2 | Chromane monobactam compounds for the treatment of bacterial infections | MERCK SHARP & DOHME LLC (US) | 2022-09-06 | — | — | US | disclosed |
| US-11357856-B2 | Lipids for delivery of active agents | Acuitas Therapeutics, Inc. (CA) | 2022-06-14 | — | — | US | disclosed |
| US-11230543-B2 | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections | MERCK SHARP & DOHME CORP. (US) | 2022-01-25 | — | — | US | disclosed |
| EP-3390357-B1 | BIARYL MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME (US) | 2021-11-10 | — | — | EP | disclosed |
| CN-113527543-A | Aqueous neutral piperidine nitrogen-oxygen free radical organic flow battery electrolyte, battery and preparation method | 西安交通大学 | 2021-10-22 | — | — | CN | disclosed |
| US-20200361928-A1 | BIARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME CORP. (US) | 2020-11-19 | — | — | US | disclosed |
| US-20200297702-A1 | CHROMANE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME CORP. (US) | 2020-09-24 | — | — | US | disclosed |
| US-6770666-B2 | A THERAPEUTIC AGENT FOR TREATING HEPATITIS C, BASED ON POLYMERASE INHIBITORY ACTIVITY | JAPAN TOBACCO INC. (JP) | 2004-08-03 | — | — | US | disclosed |
| US-20040097438-A1 | Fused-ring compounds and use thereof as drugs | JAPAN TOBACCO INC. (JP) | 2004-05-20 | — | — | US | disclosed |
| US-20040082635-A1 | Viricide against hepatitis virus; polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1400241-A1 | FUSED CYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-20030050320-A1 | Fused-ring compounds and use thereof as drugs | JAPAN TOBACCO INC. (JP) | 2003-03-13 | — | — | US | disclosed |
| EP-1162196-A1 | FUSED-RING COMPOUNDS AND USE THEREOF AS DRUGS | JAPAN TOBACCO INC. (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5470833-A | Vasodilators, bronchodilators | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-11-28 | — | — | US | disclosed |
| EP-0517103-B1 | Piperidine derivatives, a process for the preparation thereof and the use thereof | 3V SIGMA SPA (IT) | 1995-03-01 | — | — | EP | disclosed |
| US-4070461-A | ANTICHOLESTEROL | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1978-01-24 | — | — | US | disclosed |
| US-3975357-A | SUBSTITUTED PIPERIDINES | SANKYO COMPANY LIMITED (JA) | 1976-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082635-A1 | Viricide against hepatitis virus; polymerase inhibitor | HAVCR2, ZC3HAV1, POLR1C | TSHR 4757/4885NFKB1 1132/4885CYP2C19 1219/4885 |
| US-20030050320-A1 | Fused-ring compounds and use thereof as drugs | HAVCR2, ZC3HAV1, HLA-C | TSHR 4787/4885NFKB1 992/4885CYP2C19 501/4885 |
| US-11433055-B2 | Chromane monobactam compounds for the treatment of bacterial infections | MGAM, MGAM2, CMBL | TSHR 4413/4885NFKB1 436/4885CYP2C19 83/4885 |
| US-20040097438-A1 | Fused-ring compounds and use thereof as drugs | HAVCR2, ZC3HAV1, SLC10A1 | TSHR 4506/4885NFKB1 1146/4885CYP2C19 329/4885 |
| US-11230543-B2 | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections | SQLE, ABCB11, BMX | TSHR 4082/4885NFKB1 593/4885CYP2C19 150/4885 |
| US-20200361928-A1 | BIARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS | ABCB11, SQLE, BMX | TSHR 4015/4885NFKB1 539/4885CYP2C19 154/4885 |
| US-20200297702-A1 | CHROMANE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MGAM, MGAM2, CMBL | TSHR 4166/4885NFKB1 388/4885CYP2C19 82/4885 |
| US-11357856-B2 | Lipids for delivery of active agents | SGMS1, PHOSPHO1, LRAT | TSHR 1715/4885NFKB1 613/4885CYP2C19 4204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.