Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.50 |
| ▸ | CTSD | P07339 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479538 | 0.88 | ALDH1A1 (0.55) | BACE1CTSDALDH1A1KDM4EHPGD | |
| SCHEMBL27719849 | 0.85 | BACE1 (0.43) | BACE1CTSDALDH1A1KDM4EHPGD | |
| SCHEMBL4480681 | 0.85 | BACE1 (0.74) | BACE1CTSDBACE2 | |
| SCHEMBL4480903 | 0.83 | BACE1 (0.43) | BACE1CTSDALDH1A1KDM4EHPGD | |
| SCHEMBL4494789 | 0.69 | KDM4E (0.69) | BACE1CTSDALDH1A1KDM4EHPGD | |
| SCHEMBL4452759 | 0.69 | ALDH1A1 (0.59) | BACE1CTSDALDH1A1KDM4EHPGD | |
| SCHEMBL8269488 | 0.68 | BACE1 (0.77) | BACE1CTSDBACE2 | |
| SCHEMBL17674338 | 0.68 | L3MBTL1 (0.77) | BACE1CTSDALDH1A1KDM4EHPGD | |
| SCHEMBL8269561 | 0.68 | BACE1 (0.77) | BACE1CTSDBACE2 | |
| SCHEMBL8269481 | 0.67 | BACE1 (1.00) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |