Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 14/20 | 0.61 |
| ▸ | CTSL | P07711 | 10/20 | 0.61 |
| ▸ | CTSK | P43235 | 7/20 | 0.61 |
| ▸ | CTSB | P07858 | 2/20 | 0.61 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532311 | 0.90 | CTSS (0.64) | CTSSCTSLCTSKCTSBCPB2 | |
| SCHEMBL6876611 | 0.87 | CTSS (0.61) | CTSSCTSLCTSKCTSBMMP1 | |
| SCHEMBL5527567 | 0.86 | CTSS (0.78) | CTSSCTSLCTSKCTSBCPB2 | |
| SCHEMBL5527644 | 0.83 | CTSS (0.72) | CTSSCTSLCTSKCTSB | |
| SCHEMBL5523069 | 0.83 | CTSS (0.63) | CTSSCTSLCTSKCTSBMMP1 | |
| SCHEMBL5529201 | 0.82 | CTSL (0.77) | CTSSCTSLCTSKCTSB | |
| SCHEMBL5520633 | 0.81 | CPB2 (0.55) | CTSSCTSLCTSKCTSBCPB2 | |
| SCHEMBL5842372 | 0.81 | CTSS (0.66) | CTSSCTSLCTSK | |
| SCHEMBL5842376 | 0.81 | CTSS (0.66) | CTSSCTSLCTSK | |
| SCHEMBL6061517 | 0.79 | CTSS (0.52) | CTSSCTSLCTSKCTSBCPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015755-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | US | disclosed |
| US-20040147745-A1 | Novel compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | US | disclosed |
| EP-1178958-B1 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARM INC (US) | 2004-02-18 | — | — | EP | disclosed |
| US-20030096796-A1 | Novel compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2003-05-22 | — | — | US | disclosed |
| US-6455502-B1 | Compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096796-A1 | Novel compounds and compositions as protease inhibitors | CTRL, SERPINB1, CPN1 | CTSS 10/4885CTSL 14/4885CTSK 32/4885 |
| US-20040147745-A1 | Novel compounds and compositions as protease inhibitors | CTRL, SERPINB1, CPN1 | CTSS 10/4885CTSL 14/4885CTSK 32/4885 |
| US-20070015755-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | CTRL, SERPINB1, CPN1 | CTSS 10/4885CTSL 14/4885CTSK 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.