Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | GAPDH | P04406 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.54 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5522483 | 1.00 | MAPT (0.54) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL5523607 | 0.83 | CHRNA7 (0.76) | MAPTKDM4EMEN1ALDH1A1ALOX15 | |
| SCHEMBL5522476 | 0.83 | CHRNA7 (0.76) | MAPTKDM4EMEN1ALDH1A1ALOX15 | |
| SCHEMBL5516230 | 0.83 | CHRNA7 (0.76) | MAPTKDM4EMEN1ALDH1A1ALOX15 | |
| SCHEMBL16171094 | 0.79 | GRK6 (0.78) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL15300053 | 0.79 | GRK6 (0.78) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL16168697 | 0.79 | MAPT (0.54) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL16406037 | 0.79 | MAPT (0.63) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL14435011 | 0.79 | CHRNA7 (0.46) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL14435006 | 0.79 | CHRNA7 (0.46) | MAPTKDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | claimed |
| EP-1631288-A1 | POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | AstraZeneca AB (SE) | 2006-03-08 | — | — | EP | claimed |
| WO-2004098600-A1 | POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | CHRNA1, CHRNA2, CHRM1 | MAPT 1307/4885KDM4E 2662/4885MEN1 3049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.