Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5524400 | 0.78 | MAPT (0.40) | MAPTKDM4ECYP1A2CYP1B1CYP3A4 | |
| SCHEMBL4538637 | 0.76 | LTA4H (0.40) | MAPTKDM4ECYP1A2CYP1B1CYP3A4 | |
| SCHEMBL4192166 | 0.71 | MAPT (0.52) | MAPTKDM4ECYP1A2CYP1B1CYP3A4 | |
| SCHEMBL14697272 | 0.71 | MAPT (0.52) | MAPTKDM4ECYP1A2CYP1B1CYP3A4 | |
| SCHEMBL5526745 | 0.71 | HTR2A (0.34) | MAPTKDM4ECYP1A2CYP1B1LTA4H | |
| SCHEMBL14064172 | 0.70 | HTR1A (0.44) | CYP3A4HTR1A | |
| SCHEMBL4183102 | 0.69 | ALDH1A1 (0.34) | CYP1A2CYP1B1LMNAMEN1HTT | |
| SCHEMBL4335133 | 0.67 | LMNA (0.39) | MAPTCYP1A2CYP1B1CYP3A4HTR1A | |
| SCHEMBL9413226 | 0.66 | LTA4H (0.47) | MAPTKDM4ECYP1A2LTA4HLMNA | |
| SCHEMBL5584234 | 0.65 | MAPT (0.43) | MAPTKDM4ECYP1A2CYP1B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | claimed |