Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27498542 | 1.00 | OPRM1 (0.49) | OPRM1OPRK1KCNA5SCN5AKDM4E | |
| SCHEMBL30117306 | 0.82 | KCNA5 (0.65) | OPRM1OPRK1KCNA5SCN5AKDM4E | |
| Hydrochloric Acid SCHEMBL9068002 | 0.80 | ALDH1A1 (0.51) | OPRM1OPRK1KCNA5SCN5AKDM4E | |
| SCHEMBL14436556 | 0.79 | KCNA5 (0.67) | KCNA5SCN5AKDM4EALDH1A1CYP2C9 | |
| SCHEMBL12391702 | 0.79 | KCNA5 (0.67) | KCNA5SCN5AKDM4EALDH1A1CYP2C9 | |
| SCHEMBL8918959 | 0.79 | KCNA5 (0.67) | KCNA5SCN5AKDM4EALDH1A1CYP2C9 | |
| SCHEMBL2624926 | 0.79 | KCNA5 (0.67) | KCNA5SCN5AKDM4EALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL1762321 | 0.78 | KCNA5 (0.66) | KCNA5SCN5AKDM4EALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL5949068 | 0.78 | KCNA5 (0.66) | KCNA5SCN5AKDM4EALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL1762340 | 0.78 | KCNA5 (0.66) | KCNA5SCN5AKDM4EALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130171077-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2013-07-04 | — | — | US | disclosed |
| US-20070190156-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130171077-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | OPRM1 189/4885OPRK1 167/4885KCNA5 26/4885 |
| US-20070190156-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | OPRM1 189/4885OPRK1 167/4885KCNA5 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.