Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 16/20 | 0.64 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239592 | 0.85 | IMPDH2 (0.63) | IMPDH2 | |
| SCHEMBL5614088 | 0.85 | IMPDH2 (0.63) | IMPDH2 | |
| SCHEMBL5524963 | 0.82 | IMPDH2 (0.67) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5524971 | 0.82 | IMPDH2 (0.67) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5531753 | 0.81 | IMPDH2 (0.66) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5531750 | 0.81 | IMPDH2 (0.66) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6170243 | 0.78 | IMPDH2 (0.73) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5524839 | 0.77 | IMPDH2 (0.58) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5524834 | 0.77 | IMPDH2 (0.58) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5524831 | 0.77 | IMPDH2 (0.58) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765336-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS-HOPKINS UNIVERSITY (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006004795-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-01-12 | — | — | WO | disclosed |