Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5531051 | 0.78 | HTR3E (0.47) | MAPTALDH1A1KMT2ANPSR1MEN1 | |
| SCHEMBL5524866 | 0.78 | ALDH1A1 (0.55) | MAPTALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL5524860 | 0.78 | ALDH1A1 (0.55) | MAPTALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL5527790 | 0.77 | GAA (0.60) | MAPTALDH1A1KMT2AHTTNPSR1 | |
| SCHEMBL5530804 | 0.75 | ALDH1A1 (0.58) | MAPTALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL14448337 | 0.73 | ALDH1A1 (0.57) | MAPTALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL6686206 | 0.70 | NPC1 (0.46) | MAPTALDH1A1KMT2AHTTL3MBTL1 | |
| SCHEMBL13234933 | 0.69 | MAPT (0.76) | MAPTALDH1A1KMT2AHTTMAPK1 | |
| SCHEMBL28432321 | 0.69 | MAPT (0.64) | MAPTALDH1A1KMT2AHTTNPSR1 | |
| SCHEMBL5527844 | 0.67 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203140-A1 | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-30 | — | — | US | claimed |
| WO-2007095050-A2 | N-HYDROXYGUANIDINES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-08-23 | — | — | WO | claimed |
| US-20070203140-A1 | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-30 | — | — | US | disclosed |
| US-20070203140-A1 | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-30 | — | — | US | disclosed |
| WO-2007095050-A2 | N-HYDROXYGUANIDINES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203140-A1 | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, HNMT | MAPT 2160/4885ALDH1A1 764/4885KMT2A 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.