Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5531051 | 0.80 | HTR3E (0.47) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL5530801 | 0.78 | ALDH1A1 (0.57) | ALDH1A1HSD17B10KDM4ESMN1; SMN2EPHX2 | |
| SCHEMBL5530797 | 0.78 | ALDH1A1 (0.57) | ALDH1A1HSD17B10KDM4ESMN1; SMN2EPHX2 | |
| SCHEMBL5527790 | 0.76 | GAA (0.60) | ALDH1A1HSD17B10SMN1; SMN2KMT2ALMNA | |
| SCHEMBL5524871 | 0.75 | MAPT (0.53) | ALDH1A1HSD17B10SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14448355 | 0.73 | ALDH1A1 (0.59) | ALDH1A1HSD17B10KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL5527844 | 0.71 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL3578857 | 0.69 | SLC6A7 (0.78) | ALDH1A1HSD17B10KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL5481399 | 0.69 | KDM4E (0.77) | ALDH1A1HSD17B10KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL5481404 | 0.69 | KDM4E (0.77) | ALDH1A1HSD17B10KDM4ESMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203140-A1 | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-30 | — | — | US | claimed |
| WO-2007095050-A2 | N-HYDROXYGUANIDINES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-08-23 | — | — | WO | claimed |
| US-20070203140-A1 | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203140-A1 | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, HNMT | ALDH1A1 764/4885HSD17B10 685/4885BCHE 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.