Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.36 |
| ▸ | CBFB | Q13951 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA7 | P43166 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3305314 | 1.00 | MAPT (0.36) | MAPTALDH1A1GAAHPGDHTT | |
| Deferitrin SCHEMBL18103545 | 0.90 | TYR (0.35) | MAPTALDH1A1GAAHPGDHTT | |
| Deferitrin SCHEMBL663744 | 0.90 | TYR (0.35) | MAPTALDH1A1GAAHPGDHTT | |
| Deferitrin SCHEMBL1272026 | 0.90 | TYR (0.35) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL27593508 | 0.86 | NPC1 (0.35) | MAPTALDH1A1HPGDCA1CA2 | |
| SCHEMBL3303995 | 0.84 | NPC1 (0.40) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL3303985 | 0.84 | NPC1 (0.40) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL13408606 | 0.84 | ACMSD (0.34) | MAPTALDH1A1GAAHPGDPTGS2 | |
| SCHEMBL1534233 | 0.83 | HTR2B (0.44) | MAPTALDH1A1HPGDNPC1HTR2B | |
| SCHEMBL3306772 | 0.82 | CA12 (0.41) | MAPTALDH1A1GAAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232664-A1 | Iron binding agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
| US-7144904-B2 | desferrithiocin analogs used as siderophores, for treatment of malaria in humans | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20050245579-A1 | Iron binding agents | BERGERON RAYMOND J JR | 2005-11-03 | — | — | US | disclosed |
| US-6864270-B2 | Iron binding agents | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2005-03-08 | — | — | US | disclosed |
| EP-1488791-A2 | Antimalarial agents | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2004-12-22 | — | — | EP | disclosed |
| US-20030083349-A1 | Iron binding agents | UNIVERSITY OF FLORIDA (US) | 2003-05-01 | — | — | US | disclosed |
| EP-1143951-A2 | ANTIMALARIAL AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000016763-A2 | ANTIMALARIAL AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232664-A1 | Iron binding agents | TFRC, SLC40A1, FECH | MAPT 1546/4885ALDH1A1 2200/4885GAA 1378/4885 |
| US-20050245579-A1 | Iron binding agents | TFRC, SLC40A1, FECH | MAPT 1546/4885ALDH1A1 2200/4885GAA 1378/4885 |
| US-20030083349-A1 | Iron binding agents | TFRC, SLC40A1, FECH | MAPT 1546/4885ALDH1A1 2200/4885GAA 1378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.