Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303985 | 1.00 | NPC1 (0.40) | NPC1GAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3301483 | 0.91 | NPC1 (0.40) | NPC1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3301476 | 0.91 | NPC1 (0.40) | NPC1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL11963474 | 0.86 | SLC22A12 (0.38) | — | |
| SCHEMBL13390767 | 0.85 | TSHR (0.42) | NPC1GAAMEN1KMT2AMAPT | |
| SCHEMBL3305314 | 0.84 | MAPT (0.36) | NPC1GAAMAPTHPGDALDH1A1 | |
| SCHEMBL5525608 | 0.84 | MAPT (0.36) | NPC1GAAMAPTHPGDALDH1A1 | |
| SCHEMBL11963295 | 0.84 | SLC22A12 (0.37) | KDM4E | |
| SCHEMBL11963298 | 0.84 | SLC22A12 (0.37) | KDM4E | |
| SCHEMBL3302488 | 0.84 | SLC22A12 (0.37) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| EP-2137170-B1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIV FLORIDA (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-9174948-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20130210870-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-8324397-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| EP-2137170-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008115433-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | HAMP, SLC40A1, FTH1 | NPC1 1538/4885GAA 4573/4885MEN1 1113/4885 |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | SLC40A1, HAMP, FTH1 | NPC1 1819/4885GAA 4420/4885MEN1 1267/4885 |
| US-20130210870-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | HAMP, SLC40A1, FTH1 | NPC1 1538/4885GAA 4573/4885MEN1 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.