Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29811263 | 1.00 | KDM4E (0.45) | KDM4EELANEMAPTPKMHTT | |
| SCHEMBL29891982 | 0.86 | ELANE (0.41) | KDM4EELANEMAPTPKMHTT | |
| SCHEMBL22915141 | 0.86 | ELANE (0.41) | KDM4EELANEMAPTPKMHTT | |
| SCHEMBL29811258 | 0.81 | PKM (0.44) | KDM4EMAPTPKMHTTMAPK1 | |
| SCHEMBL22239410 | 0.81 | PDE2A (0.46) | PKMNPSR1ALDH1A1BCHEACHE | |
| SCHEMBL4822294 | 0.81 | ATM (0.45) | KDM4EPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL607256 | 0.81 | PKM (0.44) | KDM4EMAPTPKMHTTMAPK1 | |
| SCHEMBL29811309 | 0.81 | ESR2 (0.41) | MAPTHTTMAPK1RAB9AMCL1 | |
| SCHEMBL2384145 | 0.81 | ESR2 (0.41) | MAPTHTTMAPK1RAB9AMCL1 | |
| SCHEMBL29811388 | 0.81 | ATM (0.45) | KDM4EPKMKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110511188-B | Preparation method of 2-imino dihydro quinazolinone compound | 烟台大学 | 2022-09-20 | — | — | CN | claimed |
| US-12478621-B2 | Substituted aminoquinolones as dgkalpha inhibitors for immune activation | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2025-11-25 | — | — | US | disclosed |
| CN-119564686-A | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-119523983-A | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119424429-A | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-115003665-B | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2024-11-08 | — | — | CN | disclosed |
| US-11998539-B2 | Substituted aminoquinolones as DGKalpha inhibitors for immune activation | BAYER AKTIENGESELLSCHAFT (DE) | 2024-06-04 | — | — | US | disclosed |
| US-20240140949-A1 | ANTI-CANCER PHARMACEUTICAL COMPOSITION FOR TARGETING HEAT SHOCK PROTEIN 70, CONTAINING INDOLOQUINAZOLIDINE ALKALOID | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2024-05-02 | — | — | US | disclosed |
| US-20230201186-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-06-29 | — | — | US | disclosed |
| US-20230201186-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-06-29 | — | — | US | disclosed |
| US-7173036-B2 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS (US) | 2007-02-06 | — | — | US | disclosed |
| US-20040204586-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS, INC. | 2004-10-14 | — | — | US | disclosed |
| EP-0135367-B1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1988-03-16 | — | — | EP | disclosed |
| US-4659718-A | VASODILATION | THE BOOTS COMPANY PLC (GB) | 1987-04-21 | — | — | US | disclosed |
| US-4537966-A | 1-(Aminobenzoyl)-1H-indazol-3-ols | PENNWALT CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0135367-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1985-03-27 | — | — | EP | disclosed |
| EP-0015065-B1 | PYRAZOLO (5,1-B) QUINAZOLIN-9(4H)-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1983-12-28 | — | — | EP | disclosed |
| US-4261997-A | 4-Alkyl-pyrazolo[5,1-b]-quinazolin-9(4H)-ones and anti-allergic compositions containing them | WARNER-LAMBERT COMPANY (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0015065-A1 | Pyrazolo (5,1-b) quinazolin-9(4H)-one derivatives, process for their preparation and pharmaceutical compositions containing them | WARNER-LAMBERT COMPANY (US) | 1980-09-03 | — | — | EP | disclosed |
| US-3947408-A | ANTIANXIETY AGENTS | AMERICAN CYANAMID COMPANY (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12478621-B2 | Substituted aminoquinolones as dgkalpha inhibitors for immune activation | DGKK, DGKG, DGKA | KDM4E 1315/4885ELANE 3411/4885MAPT 4812/4885 |
| US-11998539-B2 | Substituted aminoquinolones as DGKalpha inhibitors for immune activation | DGKK, DGKG, DGKA | KDM4E 1315/4885ELANE 3411/4885MAPT 4812/4885 |
| US-20040204586-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | MIF, MSR1, MMP12 | KDM4E 3206/4885ELANE 35/4885MAPT 4793/4885 |
| US-20230201186-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | DGKK, DGKG, DGKA | KDM4E 1315/4885ELANE 3411/4885MAPT 4812/4885 |
| US-20240140949-A1 | ANTI-CANCER PHARMACEUTICAL COMPOSITION FOR TARGETING HEAT SHOCK PROTEIN 70, CONTAINING INDOLOQUINAZOLIDINE ALKALOID | HSPH1, HSP90AB2P, HSPBP1 | KDM4E 3757/4885ELANE 4798/4885MAPT 864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.