Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MYOC | Q99972 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | F13A1 | P00488 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5535333 | 0.86 | ALDH1A1 (0.55) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL5531303 | 0.76 | PKM (0.56) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL5530519 | 0.76 | POLB (0.58) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL27761062 | 0.76 | POLB (0.55) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL5538233 | 0.76 | NPSR1 (0.57) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL5531540 | 0.75 | MAPT (0.67) | MAPTLMNAALDH1A1POLBEPHX1 | |
| SCHEMBL23462473 | 0.74 | MEN1 (0.67) | KMT2AMEN1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7025692 | 0.74 | MAPT (0.73) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7615703 | 0.74 | EPHX1 (0.60) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL11840733 | 0.74 | EPHX1 (0.85) | MAPTKMT2AMEN1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | MAPT 680/4885LMNA 2932/4885KMT2A 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.