Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307626 | 0.81 | NPC1 (0.65) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL5862676 | 0.80 | NLRP3 (0.52) | SMN1; SMN2ALDH1A1MAPTPOLBHTT | |
| SCHEMBL24420089 | 0.77 | CA1 (0.42) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL2209111 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL9754491 | 0.75 | KMT2A (0.55) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL23832111 | 0.73 | RAB9A (0.50) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL23831796 | 0.72 | MEN1 (0.61) | SMN1; SMN2NPC1RAB9ALMNAMAPT | |
| SCHEMBL9232955 | 0.72 | TAAR1 (0.37) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL30105361 | 0.72 | MEN1 (0.61) | SMN1; SMN2NPC1RAB9ALMNAMAPT | |
| SCHEMBL2010247 | 0.71 | SMN1; SMN2 (0.69) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1338599-B1 | Optically pure analogues of Camptothecin | SOD CONSEILS RECH APPLIC (FR) | 2007-02-14 | — | — | EP | disclosed |
| EP-1338599-A1 | Optically pure analogues of Camptothecin | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2003-08-27 | — | — | EP | disclosed |
| EP-1165565-B1 | OPTICALLY PURE CAMPTOTHECIN ANALOGUES | SOD CONSEILS RECH APPLIC (FR) | 2003-06-04 | — | — | EP | disclosed |
| EP-1165565-A1 | OPTICALLY PURE CAMPTOTHECIN ANALOGUES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000050427-A1 | OPTICALLY PURE CAMPTOTHECIN ANALOGUES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-08-31 | — | — | WO | disclosed |