SCHEMBL5529307

SCHEMBL5529307

O=C(O)Oc1noc2c1CN(C(=O)CCCOc1ccccc1)CC2

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 8/20 0.57
TSHR P16473 6/20 0.57
HPGD P15428 3/20 0.57
HSD17B10 Q99714 2/20 0.57
NPC1 O15118 7/20 0.50
RAB9A P51151 7/20 0.50
MAPT P10636 4/20 0.47
ALDH1A1 P00352 4/20 0.46
KMT2A Q03164 3/20 0.46
MAPK1 P28482 2/20 0.46
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
POLB P06746 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.41
PKM P14618 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5529317 0.89 MEN1 (0.50) SMN1; SMN2TSHRHPGDHSD17B10NPC1
SCHEMBL4271034 0.85 SMN1; SMN2 (0.60) SMN1; SMN2TSHRHPGDHSD17B10NPC1
SCHEMBL5531763 0.79 FKBP1A (0.53) TSHRMAPTKMT2AKDM4EPOLB
SCHEMBL2588611 0.78 SMN1; SMN2 (0.67) SMN1; SMN2TSHRHPGDHSD17B10NPC1
SCHEMBL2589526 0.76 SMN1; SMN2 (0.48) SMN1; SMN2TSHRHPGDHSD17B10NPC1
SCHEMBL15062704 0.74 LMNA (0.50) HPGDNPC1RAB9AALDH1A1GAA
SCHEMBL5532889 0.74 RAB9A (0.46) SMN1; SMN2HPGDNPC1RAB9AMAPT
SCHEMBL4267581 0.73 KMT2A (0.52) SMN1; SMN2TSHRHPGDHSD17B10NPC1
SCHEMBL5531524 0.73 ADORA2A (0.41) SMN1; SMN2HSD17B10MAPTALDH1A1KDM4E
SCHEMBL15300410 0.72 ALDH1A1 (0.47) SMN1; SMN2TSHRHSD17B10NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP claimed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP claimed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO claimed
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed