Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8755590 | 0.83 | ALDH1A1 (0.38) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 | |
| Lactic Acid SCHEMBL17631445 | 0.81 | TP53 (0.55) | TP53ALDH1A1 | |
| Acetic Acid SCHEMBL4551735 | 0.80 | ALDH1A1 (0.41) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 | |
| Bicarbonate SCHEMBL1081463 | 0.80 | LMNA (0.44) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 | |
| Lactic Acid SCHEMBL28116974 | 0.79 | TP53 (0.42) | TP53KMT2AALDH1A1KDM4EMEN1 | |
| Lactic Acid SCHEMBL28418627 | 0.78 | TP53 (0.58) | TP53 | |
| L-Lactic Acid SCHEMBL29395214 | 0.78 | TP53 (0.65) | TP53ALDH1A1LMNA | |
| Lactic Acid SCHEMBL453357 | 0.78 | TP53 (0.65) | TP53ALDH1A1LMNA | |
| Lactic Acid SCHEMBL18398168 | 0.78 | TP53 (0.65) | TP53ALDH1A1LMNA | |
| Acrylic Acid SCHEMBL3891399 | 0.78 | LMNA (0.59) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070212765-A1 | Method for preparing an organic amine | PURAC BIOCHEM B.V. (NL) | 2007-09-13 | — | — | US | disclosed |
| US-6291708-B1 | COMBINING AQUEOUS DILUENT, AMMONIUM SALT OF ORGANIC ACID, AND ALCOHOL; HEATING UNDER PRESSURE TO DECOMPOSE THE AMMONIUM SALT OF THE ORGANIC ACID INTO AMMONIA AND FREE ORGANIC ACID WHILE REMOVING AMMONIA; RECOVERING ACID | A.E. STALEY MANUFACTURING CO. | 2001-09-18 | — | — | US | disclosed |