Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315401 | 0.86 | NPSR1 (0.44) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL5537087 | 0.82 | LMNA (0.53) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL24262593 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL4328794 | 0.81 | NPSR1 (0.43) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL5532677 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL5531193 | 0.79 | LMNA (0.49) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL4149319 | 0.78 | LMNA (0.51) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL4153042 | 0.78 | RAB9A (0.46) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL3983952 | 0.78 | LMNA (0.48) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL17925636 | 0.77 | LMNA (0.47) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161639-A1 | Hiv integrase inhibitors | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161639-A1 | Hiv integrase inhibitors | DPYD, DUT, TYMP | SMN1; SMN2 3997/4885LMNA 2868/4885L3MBTL1 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.