Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4141251 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL5529441 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL4746430 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL3982597 | 0.78 | LMNA (0.44) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL3985585 | 0.77 | LMNA (0.44) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL16180401 | 0.76 | SCD (0.39) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL4744605 | 0.76 | LMNA (0.45) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL3983664 | 0.76 | LMNA (0.42) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT | |
| SCHEMBL5531313 | 0.76 | SCD (0.41) | SMN1; SMN2LMNAL3MBTL1NCOA3MEN1 | |
| SCHEMBL4323891 | 0.75 | SIGMAR1 (0.40) | SMN1; SMN2LMNAL3MBTL1NCOA3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161639-A1 | Hiv integrase inhibitors | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161639-A1 | Hiv integrase inhibitors | DPYD, DUT, TYMP | SMN1; SMN2 3997/4885LMNA 2868/4885L3MBTL1 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.