SCHEMBL5525684

SCHEMBL5525684

C#CCNC(=O)Oc1noc2c1CN(C(=O)c1cccc(C)c1)CC2

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.41
GRM1 Q13255 1/20 0.39
CYP3A4 P08684 2/20 0.39
HPGD P15428 1/20 0.39
HSP90AA1 P07900 6/20 0.39
ITGB2 P05107 1/20 0.39
ICAM1 P05362 1/20 0.39
ITGAL P20701 1/20 0.39
CDK4 P11802 1/20 0.38
CCND1 P24385 1/20 0.38
KDM4E B2RXH2 1/20 0.36
EPHX2 P34913 1/20 0.36
ALDH1A1 P00352 2/20 0.35
NAMPT P43490 1/20 0.35
CYP1A2 P05177 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2579206 0.85 HSP90AA1 (0.52) GRM5GRM1HPGDHSP90AA1MAPT
SCHEMBL15300254 0.70 HTR1A (0.46) ALDH1A1
SCHEMBL5538970 0.70 HSP90AA1 (0.41) GRM5HSP90AA1ALDH1A1NAMPTMAPT
SCHEMBL5528804 0.69 HPGD (0.40) HPGDHSP90AA1ALDH1A1MAPT
SCHEMBL5526654 0.69 ALDH1A1 (0.35) GRM5HPGDHSP90AA1CDK4CCND1
SCHEMBL5532995 0.69 HSD11B1 (0.45) GRM5HSP90AA1NAMPT
SCHEMBL2584773 0.67 HPGD (0.51) GRM5CYP3A4HPGDCDK4CCND1
SCHEMBL8240452 0.67 TSHR (0.49) GRM5HPGDHSP90AA1
SCHEMBL5527334 0.66 HPGD (0.46) HPGDALDH1A1MAPT
SCHEMBL5539180 0.65 HPGD (0.52) GRM5HPGDHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP claimed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP claimed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO claimed
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP disclosed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO disclosed