Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.70 |
| ▸ | RAD52 | P43351 | 2/20 | 0.69 |
| ▸ | PDE5A | O76074 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.65 |
| ▸ | ACP1 | P24666 | 1/20 | 0.62 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LATS1 | O95835 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270077 | 0.84 | CYP1A2 (0.62) | SIRT5RAD52PDE5APOLBACP1 | |
| SCHEMBL8270970 | 0.83 | RAD52 (0.49) | SIRT5RAD52PDE5APOLBSMARCA2 | |
| SCHEMBL13381601 | 0.82 | PDE5A (0.57) | SIRT5PDE5AACP1MEN1KMT2A | |
| SCHEMBL8268379 | 0.82 | PDE5A (0.64) | SIRT5PDE5AACP1MEN1KMT2A | |
| SCHEMBL1083831 | 0.82 | MEN1 (0.80) | RAD52PDE5APOLBSMARCA2ACP1 | |
| SCHEMBL1085482 | 0.81 | PDE5A (1.00) | SIRT5PDE5APOLBACP1MEN1 | |
| SCHEMBL8268384 | 0.80 | SIRT5 (0.61) | SIRT5PDE5APOLBACP1MEN1 | |
| SCHEMBL8269549 | 0.79 | PDE5A (0.86) | SIRT5RAD52PDE5APOLBACP1 | |
| SCHEMBL14758542 | 0.79 | RAD52 (1.00) | RAD52PDE5APOLBSMARCA2ACP1 | |
| SCHEMBL1084107 | 0.78 | SMN1; SMN2 (0.81) | RAD52PDE5APOLBSMARCA2HMOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197509-A1 | Compositions and methods for modulating gated ion channels | PAINCEPTOR PHARMA CORPORATION (CA) | 2007-08-23 | — | — | US | disclosed |
| US-20070197509-A1 | Compositions and methods for modulating gated ion channels | PAINCEPTOR PHARMA CORPORATION (CA) | 2007-08-23 | — | — | US | disclosed |
| US-20070197509-A1 | Compositions and methods for modulating gated ion channels | PAINCEPTOR PHARMA CORPORATION (CA) | 2007-08-23 | — | — | US | disclosed |
| WO-2007071055-A1 | COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197509-A1 | Compositions and methods for modulating gated ion channels | KCNN3, KCNN2, HCN3 | SIRT5 2352/4885RAD52 4694/4885PDE5A 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.