Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.76 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | ALB | P02768 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.76 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.76 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.76 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.76 |
| ▸ | HTR2B | P41595 | 1/20 | 0.76 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16922185 | 1.00 | GABRA1 (0.76) | GABRA1GABRB2KDM4ELMNAALB | |
| SCHEMBL13341897 | 0.91 | GABRB2 (0.62) | GABRA1GABRB2KDM4ELMNAALB | |
| Zolpidem SCHEMBL5606185 | 0.86 | GABRB2 (1.00) | GABRA1GABRB2KDM4ELMNAALB | |
| Zolpidem SCHEMBL80516 | 0.86 | GABRB2 (1.00) | GABRA1GABRB2KDM4ELMNAALB | |
| Zolpidem SCHEMBL15169819 | 0.85 | GABRB2 (0.97) | GABRA1GABRB2KDM4ELMNAALB | |
| SCHEMBL5630676 | 0.85 | GABRA1 (0.72) | GABRA1GABRB2KDM4ELMNAALB | |
| Zolpidem SCHEMBL2065026 | 0.85 | GABRB2 (0.97) | GABRA1GABRB2KDM4ELMNAALB | |
| Zolpidem SCHEMBL2064875 | 0.85 | GABRB2 (0.97) | GABRA1GABRB2KDM4ELMNAALB | |
| Zolpidem SCHEMBL28577249 | 0.85 | GABRB2 (0.97) | GABRA1GABRB2KDM4ELMNAALB | |
| Zolpidem SCHEMBL5766080 | 0.85 | GABRB2 (0.97) | GABRA1GABRB2KDM4ELMNAALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122874-A1 | COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR TREATING DEPRESSION | Sunovion Inc. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122874-A1 | COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR TREATING DEPRESSION | HTR2A, HTR5A, HTR2C | GABRA1 46/4885GABRB2 58/4885KDM4E 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.