Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83046 | 0.89 | DRD2 (0.47) | SIGMAR1DRD2DRD4NR1H2NR1H3 | |
| SCHEMBL16226782 | 0.76 | SIGMAR1 (0.55) | SIGMAR1DRD4NR1H2NR1H3 | |
| SCHEMBL30109162 | 0.76 | MEN1 (0.43) | SIGMAR1DRD2DRD4BCHEABL1 | |
| SCHEMBL16640434 | 0.73 | TACR1 (0.51) | SIGMAR1DRD4BCHE | |
| SCHEMBL82746 | 0.73 | RORC (0.52) | SIGMAR1BCHE | |
| SCHEMBL21105435 | 0.73 | TACR1 (0.51) | SIGMAR1DRD4BCHE | |
| SCHEMBL2041903 | 0.72 | L3MBTL1 (0.48) | DRD2DRD4DRD3 | |
| SCHEMBL83711 | 0.70 | HRH3 (0.50) | SIGMAR1DRD2DRD3 | |
| SCHEMBL31269715 | 0.70 | NR1H2 (0.46) | DRD2DRD4NR1H2NR1H3BCHE | |
| SCHEMBL11706699 | 0.69 | MC4R (0.43) | SIGMAR1NR1H2NR1H3BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805164-A2 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | Mitsubishi Pharma Corporation (JP) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006036015-A2 | 6- (PYRIDINYL) -4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI PHARMA CORPORATION (JP) | 2006-04-06 | — | — | WO | disclosed |