Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | DRD3 | P35462 | 5/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534238 | 0.86 | KCNH2 (0.46) | KCNH2HRH1HRH2 | |
| SCHEMBL5116804 | 0.85 | KCNH2 (0.42) | KCNH2GPBAR1HTR1ADRD4HTR2A | |
| SCHEMBL2967590 | 0.83 | KCNH2 (0.44) | KCNH2GPBAR1HTR1ADRD4HTR2A | |
| SCHEMBL4125747 | 0.82 | KCNH2 (0.48) | KCNH2GPBAR1CD274DRD2DRD3 | |
| SCHEMBL1619458 | 0.78 | FAAH (0.46) | KCNH2CD274DRD2DRD3CYP2C9 | |
| SCHEMBL4669235 | 0.77 | KCNH2 (0.44) | KCNH2GPBAR1HTR1ADRD4HTR2A | |
| SCHEMBL4668187 | 0.76 | KCNH2 (0.44) | KCNH2HRH1CD274DRD2DRD3 | |
| SCHEMBL5315964 | 0.75 | CD274 (0.54) | KCNH2CD274DRD2DRD3CCR3 | |
| SCHEMBL5318392 | 0.74 | CD274 (0.58) | KCNH2CD274DRD2DRD3CCR3 | |
| SCHEMBL4668152 | 0.74 | KCNH2 (0.44) | KCNH2HTR1ADRD4HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765831-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | claimed |
| WO-2005123747-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | claimed |