Acetic Acid

Acetic Acid

SCHEMBL5533726

CC(=O)O.CC(N)Cc1cc2ccccc2[nH]1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.52
MTNR1B P49286 1/20 0.52
LOXL2 Q9Y4K0 1/20 0.50
ADAMTS4 O75173 1/20 0.49
DPP4 P27487 2/20 0.46
KDM4E B2RXH2 3/20 0.45
MAPT P10636 1/20 0.45
DAO P14920 1/20 0.45
HPGD P15428 1/20 0.45
SRD5A2 P31213 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ALOX5 P09917 1/20 0.45
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27324837 0.91 LOXL2 (0.59) LOXL2DPP4
SCHEMBL2074734 0.91 LOXL2 (0.59) LOXL2DPP4
SCHEMBL12936626 0.84 MTNR1A (0.54) MTNR1AMTNR1BLOXL2ADAMTS4DPP4
SCHEMBL29440959 0.82 ALPI (0.54) MTNR1AMTNR1BLOXL2ADAMTS4DPP4
SCHEMBL2700469 0.82 ALPI (0.54) MTNR1AMTNR1BLOXL2ADAMTS4DPP4
SCHEMBL5159413 0.82 ADAMTS4 (0.54) MTNR1AMTNR1BLOXL2ADAMTS4KDM4E
SCHEMBL45382 0.82 ALPI (0.54) MTNR1AMTNR1BLOXL2ADAMTS4DPP4
SCHEMBL29574121 0.82 ALPI (0.54) MTNR1AMTNR1BLOXL2ADAMTS4DPP4
SCHEMBL4393088 0.82 ALPI (0.54) MTNR1AMTNR1BLOXL2ADAMTS4DPP4
Acetic Acid SCHEMBL30839816 0.80 MTNR1A (0.59) MTNR1AMTNR1BLOXL2ADAMTS4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1848412-A2 TRANSDERMAL SYSTEMS HAVING CONTROL DELIVERY SYSTEM MYLAN TECHNOLOGIES, INC. (US) 2007-10-31 EP disclosed
WO-2006091442-A2 TRANSDERMAL SYSTEMS HAVING CONTROL DELIVERY SYSTEM MYLAN TECHNOLOGIES, INC. (US) 2006-08-31 WO disclosed
WO-2004052336-A2 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE DURECT CORPORATION (US) 2004-06-24 WO disclosed