Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Embusartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Embusartan SCHEMBL5537210 | 1.00 | BDKRB1 (0.38) | BDKRB1AGTR1AGTR2 | |
| Embusartan SCHEMBL29409583 | 0.95 | BDKRB1 (0.41) | BDKRB1AGTR1AGTR2 | |
| Embusartan SCHEMBL167147 | 0.95 | BDKRB1 (0.41) | BDKRB1AGTR1AGTR2 | |
| Embusartan SCHEMBL5537214 | 0.94 | — | — | |
| SCHEMBL5814612 | 0.87 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL8013981 | 0.86 | AGTR1 (0.39) | AGTR1AGTR2 | |
| SCHEMBL8009750 | 0.86 | — | — | |
| SCHEMBL8007180 | 0.86 | — | — | |
| SCHEMBL8433566 | 0.86 | — | — | |
| Embusartan SCHEMBL20357900 | 0.85 | AGTR2 (0.47) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007003271-A1 | SALT OF EMBUSARTAN | BAYER HEALTHCARE AG (DE) | 2007-01-11 | — | — | WO | claimed |
| WO-2007003271-A1 | SALT OF EMBUSARTAN | BAYER HEALTHCARE AG (DE) | 2007-01-11 | — | — | WO | disclosed |