Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.55 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | HNF4A | P41235 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1919550 | 0.82 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL29876454 | 0.82 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL1168140 | 0.82 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL8420159 | 0.81 | HNF4A (0.63) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL28429427 | 0.81 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL8081427 | 0.81 | HNF4A (0.69) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL8747590 | 0.80 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL18076755 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL13504677 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL15060465 | 0.78 | G6PD (0.69) | ALDH1A1HPGDKDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805155-A1 | THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047344-A1 | THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |