Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | ACR | P10323 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619491 | 0.74 | MAPT (0.47) | MMP2PRSS1ACRMMP3MAPT | |
| SCHEMBL4499300 | 0.70 | MMP2 (0.50) | MMP2PRSS1ACRMMP3MAPT | |
| SCHEMBL1619492 | 0.66 | ALDH1A1 (0.41) | PRSS1ACRMAPTALDH1A1CA1 | |
| SCHEMBL4498438 | 0.66 | MMP2 (0.63) | MMP2MMP3MAPTALDH1A1CYP19A1 | |
| SCHEMBL13343452 | 0.64 | ALDH1A1 (0.43) | MAPTALDH1A1CA1CA2CA9 | |
| SCHEMBL1778964 | 0.64 | KDM4E (0.46) | ALDH1A1HRH1 | |
| SCHEMBL5971888 | 0.64 | HRH3 (0.54) | ALDH1A1 | |
| SCHEMBL21595642 | 0.64 | MMP2 (0.67) | MMP2MMP3MAPTALDH1A1CYP19A1 | |
| SCHEMBL3143891 | 0.63 | HRH3 (0.53) | ALDH1A1 | |
| SCHEMBL1894004 | 0.63 | CA2 (0.55) | ALDH1A1CYP19A1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765831-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123747-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |