SCHEMBL5540139

SCHEMBL5540139

O=Cc1ccc(NCc2ccc(Cl)cc2)cc1NC(=O)c1sc2ccccc2c1Cl

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRSS12 P56730 12/20 0.79
F10 P00742 8/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5535843 0.89 PRSS12 (1.00) PRSS12F10
SCHEMBL2721565 0.86 PRSS12 (0.81) PRSS12F10
SCHEMBL5542108 0.77 PRSS12 (0.74) PRSS12F10
SCHEMBL10246445 0.77 MAPT (0.57) PRSS12F10
SCHEMBL5540302 0.77 RAB9A (0.56) PRSS12F10
SCHEMBL10246561 0.77 PRSS12 (0.67) PRSS12F10
SCHEMBL6594521 0.75 F10 (1.00) PRSS12F10
SCHEMBL2733479 0.75 PRSS12 (1.00) PRSS12F10
SCHEMBL6592228 0.74 PRSS12 (0.83) PRSS12F10
SCHEMBL6590441 0.73 F10 (1.00) PRSS12F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012059442-A2 NEUROTRYPSIN INHIBITORS NEUROTUNE AG (CH) 2012-05-10 WO disclosed