Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | PGR | P06401 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5538068 | 0.77 | MAPT (0.39) | KMT2ANPC1RAB9AKCNMA1KDM4E | |
| SCHEMBL5538119 | 0.74 | RAB9A (0.46) | ALDH1A1HPGDKMT2ANPC1RAB9A | |
| SCHEMBL5540369 | 0.71 | CPT2 (0.40) | ALDH1A1KMT2ATRPV1TP53KDM4E | |
| SCHEMBL5548741 | 0.71 | SMN1; SMN2 (0.41) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5545017 | 0.69 | ALDH1A1 (0.41) | ALDH1A1HPGDKMT2ANPC1RAB9A | |
| SCHEMBL5540374 | 0.68 | CXCR5 (0.38) | ALDH1A1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL5545021 | 0.68 | EPHX2 (0.39) | ALDH1A1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL5546201 | 0.67 | ABL1 (0.40) | KMT2AABL1TRPV1SMN1; SMN2 | |
| SCHEMBL5546893 | 0.67 | MAPT (0.40) | ALDH1A1HPGDKMT2ANPC1RAB9A | |
| SCHEMBL5540355 | 0.66 | CA1 (0.39) | ALDH1A1KMT2ANPC1RAB9ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |