Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1620786 | 0.80 | TDP1 (0.47) | TDP1POLBAPEX1GAATRPA1 | |
| SCHEMBL48545 | 0.76 | GAA (0.53) | TDP1POLBAPEX1GAACTBP2 | |
| SCHEMBL27553305 | 0.76 | LOXL2 (0.48) | TDP1POLBAPEX1GAATRPA1 | |
| SCHEMBL8271141 | 0.76 | TDP1 (0.48) | TDP1POLBAPEX1GAATRPA1 | |
| SCHEMBL3035376 | 0.75 | CES1 (0.50) | TDP1CTBP2KMT2ATP53MAPK1 | |
| SCHEMBL15066420 | 0.74 | TRPA1 (0.52) | TDP1POLBAPEX1GAATRPA1 | |
| SCHEMBL2208662 | 0.74 | GAA (0.52) | TDP1POLBAPEX1GAACTBP2 | |
| SCHEMBL3656534 | 0.73 | CTBP2 (0.53) | TDP1POLBAPEX1GAATRPA1 | |
| SCHEMBL6568394 | 0.73 | LMNA (0.44) | LMNASMN1; SMN2TP53MAPT | |
| SCHEMBL9266213 | 0.71 | TDP1 (0.49) | TDP1POLBAPEX1GAACTBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070124152-A1 | Hiv Integrase Inhibitors | GLAXOSMITHKLINE LLC | 2007-05-31 | — | — | US | disclosed |