Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Prometryn. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prometryn SCHEMBL7622 | 0.88 | MAPK1 (0.56) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| Prometryn SCHEMBL20723889 | 0.86 | GAA (0.58) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| Prometryn SCHEMBL367101 | 0.84 | MAPK1 (0.58) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| SCHEMBL29435432 | 0.81 | MAPK1 (0.50) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| SCHEMBL66639 | 0.81 | MAPK1 (0.50) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| SCHEMBL28832020 | 0.77 | SMN1; SMN2 (0.45) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| Prometon SCHEMBL9270641 | 0.76 | SMN1; SMN2 (0.53) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| Prometryn SCHEMBL7945620 | 0.76 | POLB (0.54) | TSHRMAPK1GAAKMT2AHTT | |
| SCHEMBL11746313 | 0.76 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2HSD17B10MAPK1GAA | |
| Ametryne SCHEMBL65196 | 0.76 | POLB (0.54) | TSHRMAPK1GAAKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7175990-B2 | Method of determining endometrial receptivity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-02-13 | — | — | US | disclosed |
| US-20030219836-A1 | Method of determining endometrial receptivity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-11-27 | — | — | US | disclosed |
| EP-0750511-B1 | TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR | UNIV CALIFORNIA (US) | 2003-06-11 | — | — | EP | disclosed |
| US-5925349-A | ANTIARTHRITIC AGENTS, SKIN DISORDERS, INSULIN DEPENDENT DIABETES, ANTIULCER AGENTS AND WOUND HEALING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-07-20 | — | — | US | disclosed |
| EP-0750511-A4 | TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR | UNIV CALIFORNIA (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5695752-A | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0750511-A1 | TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995024920-A1 | TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-09-21 | — | — | WO | disclosed |