Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133403 | 0.79 | PTGS2 (0.47) | ACP1PTGS2HIF1AKDM4EGAA | |
| Hydrochloric Acid SCHEMBL6133420 | 0.79 | PTGS2 (0.47) | ACP1PTGS2HIF1AKDM4EGAA | |
| SCHEMBL6133773 | 0.74 | PTGS2 (0.48) | ACP1PTGS2HIF1ATDP1ALDH1A1 | |
| SCHEMBL10594677 | 0.73 | PTGS2 (0.64) | ACP1PTGS2HIF1ATDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6133533 | 0.73 | PTGS2 (0.48) | ACP1PTGS2HIF1ATDP1ALDH1A1 | |
| SCHEMBL6828649 | 0.72 | ALDH1A1 (0.49) | PTGS2MAPTTRPV4ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL6134178 | 0.68 | ALDH1A1 (0.47) | PTGS2HIF1AKDM4ETRPV4HTT | |
| SCHEMBL6828984 | 0.67 | ALK (0.47) | HIF1AKDM4EMAPTTRPV4ALDH1A1 | |
| SCHEMBL5543566 | 0.66 | MAPK1 (0.52) | ACP1HIF1AKDM4EGAAMAPT | |
| SCHEMBL7695066 | 0.65 | MERTK (0.51) | ACP1HIF1AKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | ACP1 3058/4885PTGS2 1262/4885HIF1A 2631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.