Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 9/20 | 0.43 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531395 | 0.96 | LTA4H (0.45) | LTA4HPPIDALDH1A1NAAAALOX5 | |
| SCHEMBL31260990 | 0.92 | EPHX2 (0.47) | LTA4HPPIDALDH1A1NAAAALOX5 | |
| SCHEMBL3105598 | 0.88 | PPID (0.47) | HTTLTA4HPPIDALDH1A1ALOX5 | |
| SCHEMBL2722347 | 0.85 | ALOX5 (0.53) | LTA4HPPIDALDH1A1ALOX5TSHR | |
| SCHEMBL3107232 | 0.84 | LMNA (0.47) | HTTALDH1A1NAAAEPHX2TSHR | |
| SCHEMBL1988984 | 0.82 | EPHX2 (0.48) | HTTNAAAFOLH1EPHX2TSHR | |
| SCHEMBL291194 | 0.82 | SMN1; SMN2 (0.57) | HTTALDH1A1FOLH1EPHX2TSHR | |
| SCHEMBL7572962 | 0.81 | LTA4H (0.51) | LTA4HPPIDALDH1A1NAAAEPHX2 | |
| SCHEMBL9212182 | 0.81 | ALOX5 (0.52) | LTA4HALDH1A1ALOX5EPHX2 | |
| SCHEMBL6105604 | 0.80 | ALOX5 (0.51) | LTA4HALDH1A1ALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758870-A1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. Organon (NL) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121106-A1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. ORGANON (NL) | 2005-12-22 | — | — | WO | disclosed |