Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545015 | 0.76 | GPR6 (0.40) | KMT2AGPR6LMNANPC1SMN1; SMN2 | |
| SCHEMBL1516305 | 0.66 | HTT (0.60) | KMT2ALMNASMN1; SMN2PKMGAA | |
| SCHEMBL3533068 | 0.66 | MAPT (0.45) | KMT2AGPR6MKNK1LMNASMN1; SMN2 | |
| SCHEMBL15333128 | 0.62 | CYP1A2 (0.65) | KMT2ALMNANPC1SMN1; SMN2RAB9A | |
| SCHEMBL30739855 | 0.62 | CYP1A2 (0.65) | KMT2ALMNANPC1SMN1; SMN2RAB9A | |
| SCHEMBL30855447 | 0.58 | KMT2A (0.54) | KMT2ANPC1SMN1; SMN2RAB9AGAA | |
| SCHEMBL30848554 | 0.58 | KMT2A (0.54) | KMT2ANPC1SMN1; SMN2RAB9AGAA | |
| SCHEMBL1516316 | 0.58 | TSHR (0.54) | KMT2ALMNASMN1; SMN2MAPTPKM | |
| SCHEMBL2542357 | 0.57 | TAS1R3 (0.68) | CCR3KMT2ANPC1RAB9AATM | |
| SCHEMBL11236668 | 0.57 | RAB9A (0.71) | KMT2ALMNANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |