Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198598 | 0.81 | TP53 (0.59) | TP53MAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL5583501 | 0.78 | TP53 (0.56) | TP53MAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL1198846 | 0.78 | TP53 (0.55) | TP53MAPTALDH1A1CTSLGSTA1 | |
| SCHEMBL14998701 | 0.77 | TP53 (0.57) | TP53MAPTALDH1A1GSTA1MAPK1 | |
| SCHEMBL1198848 | 0.75 | TP53 (0.61) | TP53MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL638047 | 0.74 | MAPT (0.63) | TP53MAPTALDH1A1CTSLGSTA1 | |
| SCHEMBL30375142 | 0.74 | MAPT (0.63) | TP53MAPTALDH1A1CTSLGSTA1 | |
| SCHEMBL30317493 | 0.74 | MEN1 (0.53) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL8586004 | 0.73 | TP53 (0.62) | TP53MAPTALDH1A1GSTA1MAPK1 | |
| SCHEMBL638831 | 0.73 | TP53 (0.62) | TP53MAPTALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812112-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044753-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |