Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198848 | 0.88 | TP53 (0.61) | TP53MAPK1HTTNPSR1CYP1A2 | |
| SCHEMBL9573562 | 0.86 | ALDH1A1 (0.48) | TP53ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL5550221 | 0.85 | HTT (0.62) | TP53MAPK1HTTNPSR1CYP1A2 | |
| SCHEMBL26648967 | 0.84 | MAPK1 (0.55) | TP53MAPK1HTTNPSR1CYP1A2 | |
| SCHEMBL5583502 | 0.83 | MAPK1 (0.57) | TP53MAPK1HTTNPSR1CYP1A2 | |
| SCHEMBL11880121 | 0.82 | SMN1; SMN2 (0.50) | MAPK1HTTALDH1A1MAPTLMNA | |
| SCHEMBL8586004 | 0.82 | TP53 (0.62) | TP53MAPK1HTTNPSR1CYP1A2 | |
| SCHEMBL14998701 | 0.80 | TP53 (0.57) | TP53MAPK1HTTNPSR1CYP1A2 | |
| SCHEMBL7285934 | 0.80 | ALDH1A1 (0.49) | TP53MAPK1HTTNPSR1CYP1A2 | |
| SCHEMBL8272439 | 0.79 | LMNA (0.54) | TP53MAPK1HTTNPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119629-B2 | Carboxamide GABAA α2 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2012-02-21 | — | — | US | disclosed |
| US-20100261711-A1 | SELECTIVE ANTICONVULSANT AGENTS AND THEIR USES | WISYS TECHNOLOGY FOUNDATION (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261711-A1 | SELECTIVE ANTICONVULSANT AGENTS AND THEIR USES | WISYS TECHNOLOGY FOUNDATION (US) | 2010-10-14 | — | — | US | disclosed |
| US-20090093466-A1 | Carboxamide GABAa ALPHA2 Modulators | BRISTOL-MYERS SQUIBB COMPANY | 2009-04-09 | — | — | US | disclosed |
| WO-2009046004-A1 | CARBOXAMIDE GABAA ALPHA2 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093466-A1 | Carboxamide GABAa ALPHA2 Modulators | GABRA2, GABRB2, GABRB1 | TP53 4882/4885MAPK1 3305/4885HTT 2347/4885 |
| US-20100261711-A1 | SELECTIVE ANTICONVULSANT AGENTS AND THEIR USES | GABRA5, GABRA6, GABRA2 | TP53 4527/4885MAPK1 4060/4885HTT 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.